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KMID : 0545120200300060926
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Journal of Microbiology and Biotechnology
2020 Volume.30 No. 6 p.926 ~ p.929
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Immune-stimulating Effect of Lactobacillus plantarum Ln1 Isolated from the Traditional Korean Fermented Food, Kimchi
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Jang Hye-Ji
Yu Hyung-Seok
Lee Na-Kyoung
Paik Hyun-Dong
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Abstract
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This study aimed to determine the immune-stimulating effects of heat-killed Lactobacillus plantarum Ln1 (HK-Ln1) through the production of nitric oxide (NO) and pro-inflammatory cytokine achieved by inducing NF-κB and mitogen-activated protein kinase (MAPK)-signaling pathways in macrophages. HK-Ln1 showed higher NO and cytokine production compared to control (nonstimulated lipopolysaccharide); in addition, the expression of inducible nitric oxide synthase (iNOS) was induced through HK-Ln1treatment. The phosphorylation of IκB-α and p65 increased following treatment by HK-Ln1, which implicates IκB-α degradation and the translocation of p65 to nucleus. In addition, the phosphorylation of MAPKs, ERK 1/2, JNK, and p38 was induced following HK-Ln1 treatment.
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KEYWORD
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Lactobacillus plantarum, probiotics, heat-killed cells, immune-stimulating
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